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Welcome to your go-to

MTHFR resource


Browse MTHFR supplement bundles and testing options
exclusively from Holistic Health

Simplistic MTHFR Support

Keep it simple, just include All In One
in your supplement regimen.

– The All in One general vitamin has very low dose supports for MTHFR and the Methylation Cycle.

– This helps to ensure that MTHFR as part of the Methylation Cycle can function to some degree.

– Dr. Amy truly believes that this cycle is critical for health and wellbeing.

MTHFR Custom Supplement Bundles

When you order supplements from Holistic Health, you can be sure you’re ordering the highest quality.

– All ingredients specifically selected and implemented by Dr. Amy
for her program: The Yasko Protocol.

– All of our custom supplements are made from manufacturers in the USA and stored in a temperature and humidity controlled area.

– Supplements are manufactured in facilities that follow cGMP guidelines.

Use coupon code “MTHFR” at checkout to get 10% OFF any MTHFR Bundle!





Vitamin B MTHFR


Have 23andMe results?

Visit to input your results to understand
which supplements will work best for you.

Then, integrate your 23andMe results into The Yasko Protocol.

Find Out Which Supplements Will Work Best For You

Understand if your MTHFR supplementation is working

Consider the following at home tests from Holistic Health.
Your test results can be personally reviewed and
commented on by Dr. Amy Yasko.

There is no additional charge for this service. As always, consult with your health care professional.

Running our DNA Test can also give you additional information beyond MTHFR.

hair elements




Organix Basic

Profile Test

Urine Toxic &


Elements test

What is MTHFR?

An Excerpt by Dr. Amy

The Methylation Cycle is critical for survival. MTHFR is part of The Methylation Cycle, it is the name of a component of a nutritional pathway in the body. Part of the reason MTHFR has gained so much attention is that this specific nutritional pathway plays a role in a range of health concerns including heart disease, high cholesterol, miscarriages, among several other conditions. When MTHFR is not produced at an optimal level (due to a “SNP”) it can lower the ability for MTHFR to function properly. This can result in significant consequences as this particular nutritional pathway has been implicated as affecting all causes of mortality. While this may seem daunting, since MTHFR is a nutritional pathway, the use of supplementation may actually help to restore its activity.

Additionally, in spite of one or more serious imbalances in the pathway, an individual’s unique combination of SNPs can be viewed as the body’s effort to have The Methylation Cycle function. When considering support to bypass SNPs in the pathway, the goal is to look at the composite of SNPs and how they impact the overall function of The Methylation Cycle, as well as the effect of each individual SNP. Rather than solely focusing on a single SNP, and missing the larger interactive picture, making overall observations about the pathway in addition to looking at specific SNPs give a sense of some of the larger issues to consider in terms of the pathway as a whole.

To learn more about your SNPs, please view my newest book,
Feel Good About Your SNPs.

About Dr. Amy Yasko

Dr. Amy has a PhD in Microbiology/Immunology/Infectious Disease from Albany Medical College, along with multiple postdoctoral fellowships including Yale Medical center, Wilmont cancer center URMC, and Pediatric Infectious Disease at URMC.

She has served as a member of the scientific advisory board for NFAM (National Foundation of Alternative Medicine) and the Documenting Hope Project for chronic illness. Dr. Amy worked in biotechnology for 15 years, codeveloping the first low cost DNA synthesizer and co owned a DNA technology company as an inventor on multiple patents involving DNA and RNA technology.

Dr. Amy then shifted her focus to using more natural approaches to address complex molecular health issues by additional training and degrees in natural health including a Doctor of Natural Health, a board certified Alternative Medical Practitioner, a board certified Holistic Health Practitioner, and is a Fellow of the American Association of Integrative Medicine.

want to learn more about Nutrigenomics?

Check out the Yasko Protocol Starter Packet!

It includes a hard copy of Feel Good Nutrigenomics: Your Roadmap to Health and A Complete Series of Lectures, a 3 disk set containing 13 1/2 hours of lectures by Dr. Amy Yasko.

Questions About MTHFR?

Dr. Amy’s Forum,
where Science & Caring Meet

We invite you to join our chat group, a place for emotional support along with concrete scientific ideas and stories of hope rewarded with over 250,000 posts, 40,000 topics and almost 30,000 people. Parents chat to each other, moderators help to answer questions about Dr. Amy’s protocol, and there are regular posts from Dr. Amy herself.

Getting Started with
Our Free Resources

I want you to know that this program is unlike any other health program you will encounter. In addition, this is likely going to be a very different experience than you have ever had. This is not a one size fits all program; it truly is a customized program to give you the tools and information that fit your needs and create a personalized map for better health and wellness. Please click here for an informative list of resources that we have made available to support you in your personal health journey.